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| Drug Class: What is Fluconazole and why is it prescribed? |
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Fluconazole is used to treat fungal infections called candidiasis (also
known as thrush or yeast infections). These include vaginal infections, throat
infections, and fungal infections elsewhere in the body, such as infections
of the urinary tract, peritonitis (inflammation of the lining of the abdomen),
and pneumonia.
Fluconazole is also prescribed to guard against candidiasis in some people receiving bone marrow transplants, and is used to treat meningitis
(brain or spinal cord inflammation) caused by another type of fungus.
In addition, Fluconazole is now being prescribed for fungal infections in kidney and liver transplant patients, and fungal infections in patients with
AIDS. |
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| Drug Mechanism: How does Fluconazole work? |
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| Fluconazole is an antifungal that works by altering the membrane
around the fungus, killing the fungus without harming our own body cells. |
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| Dosage: How should you take Fluconazole? |
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You can take Fluconazole with or without meals.
Take Fluconazole exactly as prescribed, and continue taking it for as long
as your doctor instructs. You may begin to feel better after the first few days;
but it takes weeks or even months of treatment to completely cure certain fungal
infections.
Fluconazole Dose For Adults-
Fluconazole dose for vaginal infections: The usual treatment is a single
dose of Fluconazole 150 mg.
Fluconazole dose for throat infections: The usual dose of Fluconazole for candidiasis of
the mouth and throat is Fluconazole 200 mg on the first day, followed by
Fluconazole 100 mg once a day. You should see results in a few days, but
treatment should continue for at least 2 weeks to avoid a relapse. For candidiasis
of the esophagus (gullet) the usual dose is Fluconazole 200 mg on the first
day, followed by Fluconazole 100 mg once a day. A dose of Fluconazole 400 milligrams a day
can also be taken if your infection is more severe.
Treatment should continue for a minimum of 3 weeks and
for at least 2 weeks after symptoms have stopped.
Fluconazole dose for systemic (bodywide) infections: Fluconazole doses of up to 400 milligrams
per day are sometimes prescribed.
Fluconazole dose for urinary infections and peritonitis: Fluconazole doses range from
50 to 200 milligrams per day.
Fluconazole for cryptococcal meningitis: The usual dose of Fluconazole is 400 milligrams
on the first day, followed by Fluconazole 200 mg once a day. Treatment should
continue for 10 to 12 weeks once tests of spinal fluid come back negative. For
AIDS patients, a Fluconazole 200 mg dose taken once a day is recommended
to prevent relapse.
Prevention of candidiasis during bone marrow transplantation the usual dose of Fluconazole is 400 milligrams once a day. If you have kidney disease, your doctor may have
to reduce your dosage.
Fluconazole Dose For Children -
Fluconazole dose for throat infections: The usual dose of Fluconazole for candidiasis of the
mouth and throat is 6 milligrams for each 2.2 pounds of the child weight
on the first day, and 3 milligrams per 2.2 pounds once a day after that. The
duration of treatment is the same as that for adults.
Fluconazole dose for yeast infections of the esophagus: Cadidiasis in the
upper digestive canal is usually treated with a Fluconazole dose of 6 milligrams per 2.2
pounds of body weight on the first day, and half that amount once daily thereafter.
Daily Fluconazole doses of up to 12 milligrams per 2.2 pounds of body weight are sometimes
prescribed.
Fluconazole dose for systemic (bodywide) infections: Fluconazole has been given
at 6 to 12 milligrams per 2.2 pounds of weight per day.
Fluconazole dose for cryptococcal meningitis: The usual Fluconazole dose is 12 milligrams
per 2.2 pounds of body weight per day on the first day, and 6 milligrams per
2.2 pounds per day after that.
Treatment will last 10 to 12 weeks after the fungus disappears.
Fluconazole Overdose: Any medication taken in excess can have serious
consequences. If you suspect an overdose of Fluconazole, seek medical treatment immediately.
Symptoms of Fluconazole overdose may include: Hallucinations, paranoia
If you miss a dose of Fluconazole: Take the forgotten Fluconazole dose as soon as you
remember. However, if it is almost time for your next dose, skip the one you
missed and return to your regular schedule. Do not take double Fluconazole doses.
Storage instructions for Fluconazole: Fluconazole tablets should be stored at
normal room temperature. Avoid exposing them to temperatures above 86°F. Also
to store Fluconazole:
- Keep out of the reach of children.
- Store away from
heat and direct light.
- Do not store the capsule or tablet form of Fluconazole in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture
may cause Fluconazole to break down.
- Keep the oral liquid form of Fluconazole from freezing.
- Do not keep outdated Fluconazole or medicine no longer needed.
Be sure that any discarded medicine is out of the reach of children.
Preparations of Fluconazole: Suspension content per bottle is 350mg (when
diluted 10 mg per ml) and 1400 mg (when diluted 40 mg per ml). Tablets available
in 50 mg, 100 mg, 150 mg, 200 mg. Intravenous solutions are available.
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| Possible food and drug interactions when taking Fluconazole |
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If Fluconazole is taken with certain other drugs, the effects of either could
be increased, decreased, or altered. It is especially important to check with
your doctor before combining Fluconazole with the following:
- Blood-thinning drugs such as Coumadin,
- Antidiabetic drugs such as Orinase, DiaBeta, and Glucotrol,
Astemizole (Hismanal),
Cisapride (Propulsid),
Cyclosporine (Sandimmune, Neoral),
Hydrochlorothiazide (HydroDIURIL),
Phenytoin (Dilantin),
Rifabutin (Mycobutin),
Rifampin (Rifadin),
Tacrolimus (Prograf),
Terfenadine (Seldane),
Theophylline (Theo-Dur),
- Ulcer medications such as Tagamet.
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| Special information on Fluconazole |
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If you are pregnant or breastfeeding, the effects of Fluconazole
during pregnancy have not been adequately studied. If you are pregnant or plan
to become pregnant, inform your doctor immediately. Fluconazole appears in
breast milk and could affect a nursing infant. If Fluconazole is essential
to your health, your doctor may advise you to stop breastfeeding until your treatment
with Fluconazole is finished.
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| Fluconazole side effects |
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Fluconazole side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Fluconazole.
The most common Fluconazole side effect for people taking more than one dose of Fluconazole is nausea.
For women taking a single dose of Fluconazole to treat vaginal infection,
the most common Fluconazole side effects are- Abdominal pain, diarrhea, headache, and nausea; changes in taste, dizziness, and indigestion may occur less often.
Less common Fluconazole side effects may include- Abdominal pain, diarrhea, headache, skin rash, vomiting.
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