Drug Class: What is Clorpres ? an why is it prescribed?
Clorpres Mechanism: How does Clorpres work?
Clorpres Dosage: How should you take Clorpres
Possible food and drug interactions when taking Clorpres
Special information on Clorpres
Clorpres side effects
|Drug Class: What is Clorpres ? an why is it prescribed?|
|Clorpres is a combination of Clonidine and chlorthalidone. Clorpres is used to treat high blood pressure (hypertension). Clonidine decreases the levels of certain hormones in your blood. This effect allows your blood vessels (veins and arteries) to relax and decreases your blood pressure. Clonidine also slows your heart rate. Chlorthalidone is a thiazide diuretic (water pill). Chlorthalidone helps to lower your blood pressure and decrease edema (swelling or water retention) by increasing the amount of salt and water you lose in your urine. Clorpres may also be used for purposes other than those listed in this medication guide.|
|Clorpres Mechanism: How does Clorpres work?|
|Clorpres is a combination of Clonidine hydrochloride and Chlorthalidone. Clonidine hydrochloride acts relatively rapidly. The patients blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours. Clonidine stimulates alpha-adrenoreceptors in the brain stem, resulting in reduced sympathetic outflow from the central nervous system and a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact and therefore orthostatic symptoms are mild and infrequent. Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use. Tolerance may develop in some patients, necessitating a reevaluation of therapy. Chlorthalidone is a long-acting oral diuretic with antihypertensive activity. The diuretic action of Chlorthalidone commences a mean of 2.6 hours after dosing and continues for up to 72 hours. Chlorthalidone produces diuresis with increased excretion of sodium and chloride. The diuretic effects of Chlorthalidone appear to arise from similar mechanisms and the maximal effect of Chlorthalidone and the thiazides appears to be similar. The site of action appears to be the distal convoluted tubule of the nephron. The diuretic effects of Chlorthalidone lead to decreased extracellular fluid volume, plasma volume, cardiac output, total exchangeable sodium, glomerular filtration rate, and renal plasma flow. Although the mechanism of action of Chlorthalidone and related drugs is not wholly clear, sodium and water depletion appear to provide a basis for its antihypertensive effect. Like the thiazide diuretics, Chlorthalidone produces dose-related reductions in serum potassium levels, elevations in serum uric acid and blood glucose, and it can lead to decreased sodium and chloride levels.|
|Clorpres Dosage: How should you take Clorpres|
|Your doctor will tell you how much of Clorpres to take and how often. Do not take more Clorpres or take it more often than your doctor tells you to. Carefully follow your doctors instructions about any special diet. You may need to eat foods that are high in potassium (such as oranges or bananas) to prevent potassium loss while you are using Clorpres. If you miss a Clorpres dose If you miss a dose of Clorpres, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses of Clorpres. Clorpres Overdose Clorpres overdose may lead to serious consequences. Seek medical emergency immediately. Symptoms of Clorpres overdose may include • dryness of mouth, • increased thirst, • irregular heartbeat, • mood or mental changes, • muscle cramps or pain, • nausea or vomiting, • weak pulse Clorpres Storage instructions Keep Clorpres out of the reach of children in a container that small children cannot open. Store Clorpres at room temperature at 15 to 30 degrees C (59-86 degrees F). Throw away any unused amount of Clorpres after the expiration date. Preparations: Tablet- Clonidine 0.1mg + Chlorthalidone 15mg|
|Possible food and drug interactions when taking Clorpres|
|Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products with Clorpres. Make sure your doctor knows if you are also using bepridil (Vascor), digoxin (Lanoxin), lithium, mirtazapine (Remeron), medicine for depression (such as amitriptyline, nortriptyline, Anafranil, Norpramin, Pamelor, Tofranil, Vivactil), or other blood pressure medicine (such as atenolol, metoprolol, propranolol, Corgard, Inderal, Lopressor, Toprol, Tenormin). Make sure your doctor knows if you are using any medicines that make you sleepy (such as sleeping pills, cold and allergy medicine, narcotic pain killers, or sedatives). Do not drink alcohol while you are using Clorpres.|
|Special information on Clorpres|
|Most Important Fact about Clorpres Do not stop taking Clorpres suddenly. Stopping suddenly could cause severe high blood pressure, nervousness, and anxiety. To avoid falls and injuries, stand up slowly from a sitting or lying position. Clorpres will make you drowsy and may cause some dizziness. Do not use alcohol, antihistamines, prescription pain relievers, sleeping pills, and other drugs that may cause drowsiness or dizziness except under the supervision of your doctor. Clorpres precautions if you are pregnant or breastfeeding Clorpres has not been studied in pregnant women. However, studies in animals have shown that Clonidine does not cause birth defects but does cause other harmful effects in the fetus. When Chlorthalidone is used during pregnancy, it may cause side effects including jaundice, blood problems, and low potassium in the newborn infant. Be sure you have discussed this with your doctor before taking Clorpres. Both Clonidine and Chlorthalidone pass into breast milk. Chlorthalidone may decrease the flow of breast milk. Therefore, you should avoid use of Clorpres during the first month of breast-feeding. Special warnings about Clorpres It is important that your doctor check your progress at regular visits to make sure that Clorpres is working properly. Check with your doctor before you stop taking Clorpres. Your doctor may want you to reduce gradually the amount you are taking before stopping Clorpres completely. Make sure that you have enough medicine on hand to last through weekends, holidays, or vacations. You should not miss taking any doses. You may want to ask your doctor for another written prescription to carry in your wallet or purse. You can then have it filled if you run out of medicine when you are away from home. Before having any kind of surgery (including dental surgery) or emergency treatment, make sure the medical doctor or dentist in charge knows that you are taking Clorpres. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Clorpres will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using Clorpres. Clorpres may cause some people to become drowsy or less alert than they are normally. This is more likely to happen when you begin to take it or when you increase the amount of Clorpres you are taking. Make sure you know how you react to Clorpres before you drive, use machines, or do anything else that could be dangerous if you are not alert. Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help, but if the problem continues or gets worse, check with your doctor. The dizziness, lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. Drinking alcoholic beverages may also make the drowsiness worse. While you are taking Clorpres, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for long periods of time.|
|Clorpres side effects|
Why Clorpres should not be prescribed?
If you feel you have experienced an allergic reaction, stop using Clorpres and inform your doctor or pharmacist immediately.
Possible Clorpres Side effects
Less common side effects of Clorpres may include:
Rare side effects of Clorpres may include:
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