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| Drug Class: What is Product Title?> an why is it prescribed? |
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| Isordil is a type of vasodilator. Isordil relaxes blood vessels, increasing the blood and oxygen supply to your heart.
Isordil relieves the pain you can get with angina. There are several different types of tablets and capsules. Each type has a special design, to give the most effective action. Sublingual (under the tongue) or chewable tablets can also provide prompt relief as soon as chest pain indicates the start of an angina attack.
Isordil can also help to prevent pain before activities that can cause an attack (such as climbing stairs, exercise, going outdoors in cold weather, or having sex). Isosorbide dinitrate is available as chewable tablets, or sublingual (under the tongue) tablets.
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| Drug Mechanism: How does Product Title work? |
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| Isordil contains the active ingredient isosorbide dinitrate, which is a type of medicine used to enable the heart to work more easily.
Isordil works by releasing a chemical called nitric oxide. This chemical is also made naturally by the body and has the effect of making the veins and arteries relax and widen (dilate). This increases the space within the blood vessels and therefore reduces the resistance within the blood vessels, which makes it easier for the heart to pump blood around the body.
Widening the veins also decreases the volume of blood that returns to the heart in the veins with each heartbeat, and this makes it easier for the heart to pump that blood out again. As a result of both these actions, the heart requires less energy to pump the blood around the body and therefore does not need as much oxygen.
Isordil also widens the arteries within the heart, and this increases the blood and oxygen supply to the heart muscle.
The pain of angina is caused by too little oxygen reaching the heart when its workload increases, such as during exercise. Isordil makes it easier for the heart to pump blood and so decreases the amount of oxygen that the heart needs, as well as improving the oxygen supply to the heart. Isordil tablets and skin spray can therefore be used to prevent angina attacks.
Isordil is also available as sublingual tablets and sprays, which are administered under the tongue to give rapid relief from angina attacks.
Since Isordil enables the heart to pump blood more easily it can also be used in heart failure, where the hearts ability to pump blood is reduced.
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| Dosage: How should you take Product |
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| For angina (chest pain):
For regular Isordil:
Adults
To prevent chronic stable angina pectoris, the usual starting dose for swallowed, immediately released Isordil is 5 to 20 milligrams. Your doctor may increase this initial dose to 10 to 40 milligrams every 6 hours.
Children
Your doctor must determine use and dose of Isordil.
For Sunlingual Isordil
Adults
The usual sublingual starting dose of Isordil for the treatment of angina pectoris is 2.5 milligrams to 5 milligrams. Your doctor will increase this initial dose gradually until the pain subsides or side effects prove bothersome.
The usual sublingual starting dose for the prevention of an impending attack of angina pectoris is usually 5 or 10 milligrams of Isordil every 2 to 3 hours.
Children
Your doctor must determine use and dose of Isordil.
For Isordil SR
Adults
To prevent chronic stable angina pectoris with controlled-release Isordil SR, the usual initial dose is 40 milligrams. Your doctor may increase this dose from 40 to 80 milligrams given every 8 to 12 hours.
Children
Your doctor must determine use and dose of Isordil SR.
If you miss a Isordil dose
If you are taking Isordil regularly and you miss a dose, take Isordil as soon as possible. However, if the next scheduled dose is within 2 hours (or within 6 hours for extended-release capsules or tablets), skip the missed dose and go back to your regular dosing schedule. Do not double doses of Isordil.
Isordil Overdose
Isordil if taken in excess can lead to serious consequences. Seek medical emergency immediately.
Symptoms of Isordil overdose include
bloody diarrhea,
coma,
confusion,
convulsions,
fainting,
fever,
flushed and perspiring skin (later cold and blue),
nausea,
palpitations,
paralysis,
rapid decrease in blood pressure,
rapid, then difficult and slow breathing,
slow pulse,
throbbing headache,
vertigo,
visual disturbances,
vomiting
Isordil Storage instructions
Keep Isordil out of the reach of children.
Store at room temperature, approximately 25 degrees C (77 degrees F). Protect from light. Keep container tightly closed. Throw away any unused amount of Isordil after the expiration date.
Preparations: Tablet- 2.5mg, 10mg, 20mg, 30mg, 20mg RS, 40mg SR
Sublingual Tablets- 2.5mg, 5mg
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| Possible food and drug interactions when taking Product |
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| Sildenafil (Viagra) should not be taken with Isordil, as this combination can produce a significant drop in blood pressure resulting in dizziness, fainting, or even a heart attack.
There may be a risk of a drop in blood pressure causing dizziness or fainting if Isordil is taken with any of the following, which also decrease blood pressure:
- alcohol
- medicines to treat high blood pressure (antihypertensives), eg beta-blockers, ACE inhibitors, alpha-blockers, diuretics, calcium-channel blockers
- tricyclic antidepressants, eg amitriptyline
- MAOI antidepressants, eg phenelzine
- certain antipsychotic medicines
- baclofen
- sublingual apomorphine (Uprima).
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| Special information on Product |
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| Most Important Fact about Isordil
Isordil may cause severe low blood pressure (possibly marked by dizziness or fainting), especially when you stand or sit up quickly. People taking diuretic medication or those who have low blood pressure should use Isordil with caution.
Isordil precautions if you are pregnant or breastfeeding
The safety of Isordil for use during pregnancy has not been established. Isordil is not recommended for use in pregnancy unless considered essential by your doctor. Seek medical advice from your doctor.
It is not known if Isordil passes into breast milk. Isordil is not recommended for use during breastfeeding unless considered essential by your doctor. Seek medical advice from your doctor.
Special warnings about Isordil
Check your heart rate and blood pressure regularly while you are taking Isordil. Ask your prescriber or health care professional what your heart rate and blood pressure should be and when you should contact him or her. Tell your prescriber or health care professional if you feel Isordil is no longer having any effect.
You may get dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how Isordil affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, and increase flushing and rapid heartbeats. Avoid alcoholic drinks.
If you are taking Isordil on a regular schedule, do not stop taking Isordil suddenly or your symptoms may get worse. Ask your prescriber or health care professional how to gradually reduce the dose.
If you find that Isordil becomes less effective with time you should consult your doctor or pharmacist.
Isordil skin spray should be sprayed onto clean dry skin on the chest from a distance of 20cm (8 inches) and then rubbed in gently. Avoid contact with the eyes and do not inhale the spray. Keep the spray away from naked flames.
Isordil is not recommended for use in children.
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| Product Title side effects |
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| Why Isordil should not be prescribed?
Isordil should not be used if you suffer from severe anaemia, closed angle glaucoma, low blood pressure, hypovolaemia (low volume of circulating blood), cerebral haemorrhage (bleeding in the brain), cardiac tamponade (blood in the sac surrounding the heart which prevents the heart beating properly), constrictive pericarditis (inflammation of the sac surrounding the heart which stops the heart from beating properly), aortic stenosis (narrowing of the main artery coming from the heart) or mitral valve stenosis (narrowing of one of the valves in the heart).
Isordil should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using Isordil and inform your doctor or pharmacist immediately.
Possible Isordil Side effects
More common side effects of Isordil may include:
dizziness,
light-headedness,
low blood pressure,
weakness
Less common side effects of Isordil may include:
collapse,
fainting,
flushed skin,
high blood pressure,
nausea,
pallor,
perspiration,
rash,
restlessness,
skin inflammation and flaking,
vomiting
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Drug Class: What is Product Title?> an why is it prescribed?
