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| Drug Class: What is Product ? and why is it prescribed? |
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| Metaglip is a combination of Glipizide and Metformin.
Metaglip helps to treat type 2 diabetes mellitus. Treatment is combined with a balanced diet and exercise. Metaglip lowers blood sugar and helps your body to use insulin more efficiently.
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| Drug Mechanism: How does Product work? |
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| Metaglip is a combination of Glipizide and Metformin. Metaglip is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. With two actions, the combination of Glipizide and Metformin helps your body cope with high blood sugar.
Glipizide stimulates the release of insulin from the pancreas, directing your body to store blood sugar.
Metformin has three different actions: Metformin slows the absorption of sugar in your small intestine; Metformin also stops your liver from converting stored sugar into blood sugar; and Metformin helps your body use your natural insulin more efficiently.
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| Dosage: How should you take Product |
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| Take Metaglip tablets by mouth with meals. Swallow the tablets with a drink of water.
For type 2 diabetes:
For first-time treatment:
Adults:
At first, Metaglip containing 2.5 mg of Glipizide and 250 mg of Metformin once a day with a meal. Then, your doctor may increase your dose a little at a time every two weeks until your blood sugar is controlled.
Children:
Your doctor must determine use and dose of Metaglip.
As second-line therapy:
Metaglip containing 2.5 mg of Glipizide and 250 mg of Metformin two times a day, with the morning and evening meals. Then, your doctor may increase your dose a little at a time until your blood sugar is controlled. The starting dose should not exceed the daily dose of Metaglip already being taken.
Children:
Your doctor must determine use and dose of Metaglip.
If you miss a Metaglip dose
If you miss a dose of Metaglip, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses of Metaglip.
Metaglip Overdose
Metaglip overdose may lead to serious consequences. Seek medical emergency immediately.
Symptoms of Metaglip overdose may include
• abdominal discomfort,
• anxiety,
• behavior change,
• similar to drunkenness,
• blurred vision,
• cold sweats,
• coma,
• confusion,
• cool,
• pale skin,
• decreased appetite,
• diarrhea,
• difficulty in concentrating,
• drowsiness,
• excessive hunger,
• fast heartbeat,
• fast, shallow breathing ,
• general feeling of discomfort,
• headache,
• muscle pain or cramping,
• nausea,
• nervousness,
• nightmares,
• restless sleep,
• seizures,
• shakiness,
• slurred speech,
• unusual sleepiness,
• unusual tiredness or
• weakness
Metaglip Storage instructions
Keep Metaglip out of the reach of children in a container that small children cannot open.
Store Metaglip at room temperature between 15-25 degrees C (59-77 degrees F). Keep container tightly closed and protect from light. Throw away any unused amount of Metaglip after the expiration date.
Preparations: Tablet- Glipizide 2.5mg+ Metformin 250mg
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| Possible food and drug interactions when taking Product |
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| The following medications should not be taken with Metaglip
-alcohol
-antifungal medicines like fluconazole, itraconazole or miconazole
-asparaginase
-cephalexin
-chloramphenicol
-cimetidine
-cisapride
-cyclosporine
-digoxin
-dofetilide
-guanethidine
-lithium
-metoclopramide
-morphine
-niacin
-nifedipine
-octreotide
-other medicines for diabetes
-procainamide
-propantheline
-quinine
-quinidine
-ranitidine
-trimethoprim
-vancomycin
-warfarin
-water pills (diuretics like amiloride, furosemide, triamterene)
The medications listed below may cause changes (increase or decrease) in blood sugar:
-alcohol containing beverages
-aspirin and aspirin-like drugs
-beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)
-chromium
-female hormones, such as estrogens or progestins, birth control pills
-isoniazid
-male hormones or anabolic steroids
-medications for weight loss
-medicines for allergies, asthma, cold, or cough
-niacin
-pentamidine
-phenytoin
-quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)
-some herbal dietary supplements
-steroid medicines such as prednisone or cortisone
-thyroid hormones
-water pills (diuretics like amiloride, furosemide, triamterene)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Metaglip works. Check with your health care professional before stopping or starting any of your medicines.
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| Special information on Product |
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| Most Important Fact about Metaglip
Metaglip could cause a very rare but potentially fatal side effect known as lactic acidosis. It is caused by a buildup of lactic acid in the blood. The problem is most likely to occur in people whose liver or kidneys are not working well, and in those who have multiple medical problems, take several medications, or have congestive heart failure. The risk also is higher if you are an older adult or drink alcohol. Lactic acidosis is a medical emergency that must be treated in a hospital. Notify your doctor immediately if you experience any of the following:
Symptoms of lactic acidosis may include:
dizziness,
extreme weakness or tiredness,
light-headedness,
low blood pressure,
low body temperature,
slow or irregular heartbeat,
rapid breathing or trouble breathing,
sleepiness,
unexpected or unusual stomach discomfort,
unusual muscle pain
Metaglip precautions if you are pregnant or breastfeeding
Metaglip has not been studied in pregnant women or animals. However, independent studies with Glipizide and also with Metformin have not shown that either medicine causes birth defects or other problems in animal studies. It is easier during pregnancy to control your blood sugar by using injections of insulin rather than by taking oral diabetes medicines. Close control of your blood sugar can reduce the chance of your baby gaining too much weight, having birth defects, or having high blood sugar before birth. Before taking Metaglip, make sure your doctor knows if you are pregnant or if you may become pregnant.
It is not known whether Metaglip passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking Metaglip and who wish to breast-feed should discuss this with their doctor.
Special warnings about Metaglip
Some studies suggest that the Glipizide component of Metaglip may lead to more heart problems than treatment with diet alone, or diet plus insulin. In a long-term trial of a similar drug, researchers noted an increase in heart-related deaths (though the overall mortality rate remained unchanged). If you have a heart condition or youre at risk for heart disease, you should discuss this potential danger with your doctor.
Because Metaglip can cause hypoglycemia (low blood sugar), its very important to follow your doctors instructions carefully. Low blood sugar is more likely to happen if youre older, weak, or undernourished, or if you have kidney, liver, adrenal, or pituitary gland problems. Your risk also increases if you miss meals or fail to eat after doing strenuous exercise. Combining Metaglip with other diabetes medications can also cause blood sugar to drop. Symptoms of a mild case include cold sweats, dizziness, shakiness, a light-headed feeling, and hunger. Check with your doctor immediately if you notice any of these warning signs, since severe low blood sugar can occasionally lead to seizures or coma.
Before you start therapy with Metaglip, and at least once a year thereafter, your doctor will do a complete assessment of your kidney function. If you develop kidney problems while on Metaglip, your doctor will discontinue Metaglip. If you are an older person, you will need to have your kidney function monitored more frequently, and your doctor may want to start you at a lower dosage.
You should temporarily stop taking Metaglip for 2 days before and after having an X-ray procedure that uses an injectable dye. Also, if you are going to have surgery, except minor surgery, you should stop taking Metaglip. Once you have resumed normal food and fluid intake, your doctor will tell you when you can start Metaglip therapy again.
Avoid drinking too much alcohol while taking Metaglip. Heavy drinking increases the danger of lactic acidosis and can also trigger an attack of low blood sugar.
Because poor liver function could increase the risk of lactic acidosis, your doctor may decide to check your liver function before prescribing Metaglip and periodically thereafter. If you develop liver problems, your doctor may stop treatment with Metaglip.
Metaglip occasionally causes a mild deficiency of vitamin B12. Your doctor will check for this with yearly blood tests and may prescribe a supplement if necessary.
You should stop taking Metaglip if you become seriously dehydrated, since this increases the likelihood of developing lactic acidosis. Tell your doctor if you lose a significant amount of fluid due to vomiting, diarrhea, fever, or some other condition.
While taking Metaglip, you should check your blood or urine periodically for abnormal sugar levels. If you notice sudden changes after youve been stabilized for a while, tell your doctor immediately. It could be a sign youre developing lactic acidosis or ketoacidosis.
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| Product side effects |
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| Why Metaglip should not be prescribed?
Metaglip should not be used if you are allergic to one Glipizide or Metformin. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using Metaglip and inform your doctor or pharmacist immediately.
Possible Metaglip Side effects
More common side effects of Metaglip may include:
• anxiety,
• blurred vision,
• chills,
• cold sweats,
• coma,
• confusion,
• cool pale skin,
• cough,
• depression,
• dizziness,
• fast heartbeat,
• fever,
• headache,
• increased hunger,
• nausea,
• nervousness,
• nightmares,
• seizures,
• shakiness,
• slurred speech,
• sneezing,
• sore throat,
• unusual tiredness or weakness
Less common side effects of Metaglip may include:
• bladder pain,
• bloody or cloudy urine,
• difficult,
• burning, or painful urination,
• frequent urge to urinate,
• lower back or side pain,
• pounding in the ears,
• slow heartbeat
Rare side effects of Metaglip may include:
• abdominal discomfort,
• decreased appetite,
• diarrhea,
• fainting spells,
• fast, shallow breathing,
• general feeling of discomfort,
• muscle pain or cramping,
• shortness of breath,
• sleepiness
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Drug Class: What is Product ? and why is it prescribed?
