Generic Zofran may also be used to prevent or treat nausea and vomiting that occurs after surgery and radiation therapy, and occasionally is used to treat severe vomiting during pregnancy.

Anti-cancer medicines and radiotherapy may cause the release of serotonin in the small intestine, setting off the vomiting reflex. Generic Zofran blocks this process.

Thus, the effect of Generic Zofran in the management of the nausea and vomiting induced by anticancer (cytotoxic) medicines and radiotherapy is probably due to blockade of serotonin receptors on neurons located both in the brain and peripheral nervous system. The mechanisms of action in post-operative nausea and vomiting are not known but there may be common pathways with cytotoxic induced nausea and vomiting.

Prevention of Nausea and Vomiting after Surgery
Adults
The usual dose of Generic Zofran is two 8-milligram tablets or 4 teaspoonfuls of oral solution taken 1 hour before undergoing anesthesia.

Children
Generic Zofran has not been used for this purpose in children.

Prevention of Nausea and Vomiting due to Chemotherapy
Adults and Children 12 Years of Age and Older
The recommended dose of Generic Zofran is one 8-milligram tablet taken twice a day. The first dose should be taken 30 minutes before the start of treatment. The other dose should be taken 8 hours after the first dose. One 8-milligram tablet should be taken twice a day (every 12 hours) for 1 to 2 days after completing chemotherapy. If the chemotherapy is especially likely to cause nausea and vomiting, the recommended dosage is one 24-milligram tablet taken 30 minutes before the treatment.

Children 4 through 11 Years of Age
The recommended dose of Generic Zofran is one 4-milligram tablet taken 3 times a day. The first dose should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. One 4-milligram tablet should be taken 3 times a day (every 8 hours) for 1 to 2 days after completing chemotherapy.

Prevention of Nausea and Vomiting due to Radiation therapy
Adults
The usual dose of Generic Zofran is one 8-milligram tablet taken 3 times a day. You will take the first dose 1 to 2 hours before therapy; the other intervals will depend on the type of radiation therapy you are receiving.

Children
Generic Zofran has not been used for this purpose in children.

If you miss a Generic Zofran dose
If you miss a dose of Generic Zofran, and you do not feel nauseated, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of Generic Zofran, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Generic Zofran Overdose
Generic Zofran overdose can lead to serious consequences. Seek medical emergency immediately.

Symptoms of Generic Zofran overdose may include

• low blood pressure and fainting,
• sudden blindness,
• severe constipations

Generic Zofran Storage instructions
Keep Generic Zofran out of the reach of children.
Store Generic Zofran between 2 and 30 degrees C (36 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.
Generic Zofran Preparations: Tablet - 4mg, 8mg, 24mg

The drugs that may interact with Generic Zofran include

• alcohol and alcoholic beverages
• bosentan
• cisplatin
• cyclophosphamide
• delavirdine
• imatinib,
• rifabutin
• rifampin
• rifapentine
• ritonavir

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Generic Zofran works. Check with your health care professional before stopping or starting any of your medicines.

Generic Zofran precautions if you are pregnant or breastfeeding
Generic Zofran has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies.
It is not known whether Generic Zofran passes into the breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking Generic Zofran and who wish to breast-feed should discuss this with their doctor.

Special warnings about Generic Zofran
Do not take Generic Zofran if you are suffering from liver disease. You may require special dose adjustment or special monitoring during treatment.

Why Generic Zofran should not be prescribed?
Generic Zofran should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using Generic Zofran and inform your doctor or pharmacist immediately.

More common side effects of Generic Zofran may include:

• constipation,
• diarrhea,
• dizziness,
• fatigue,
• headache
• fever

Less common side effects of Generic Zofran may include:

• abdominal pain or stomach cramps,
• burning,
• tingling, or prickling sensations,
• dizziness or lightheadedness ,
• drowsiness,
• dryness of mouth,
• feeling cold,
• itching ,
• unusual tiredness or weakness

Rare side effects of Generic Zofran may include:

• chest pain,
• redness, or burning at place of injection,
• shortness of breath,
• skin rash,
• hives, and/or itching,