Generic Migranal is used to help relieve the pain of migraine headaches. Generic Migranal contains a combination of medications which work by constricting blood vessels in the head. This relieves the dilation (widening) of blood vessels, which is related to migraine headache pain.

Generic Migranal is a migraine-specific serotonin agonist that works at multiple receptor sites.

Ergotamine causes constriction of peripheral and cranial blood vessels. The amplitude of pulsations in the cranial arteries is reduced as is also extracranial blood flow.

Ergotamine also reduces hyperfusion in the basilar artery territory.

Caffeine potentiates the action of Ergotamine.

Generic Migranal attacks migraine at its source by selectively binding to receptors in the brain that regulate the release of serotonin, a chemical considered to play a key role in the development of migraine.

Generic Migranal comes in the form of tablets as well as rectal suppositories. Your prescription label tells you how much to take at each dose. The directions below are examples of common instructions.

• Take two tablets of Generic Migranal at the first sign of a migraine headache.
• Lie down and relax in a quiet, dark room for at least two hours.

If Generic Migranal is taken with certain other drugs, the effects of either can be increased, decreased, or altered. Completely avoid other migraine remedies and ergotamine-based drugs, and check with your doctor before combining Generic Migranal with the following:

• Azithromycin (Zithromax)
• Clarithromycin (Biaxin)
• Erythromycin (Ery-Tab, Eryc)
• Nicotine (from any source, including cigarettes, patches, or inhalers)
• Phenylpropanolamine (Propagest)
• Propranolol (Inderal)
• Pseudoephedrine (Afrin, Sudafed)
• Troleandomycin (Tao)

Most Important Fact about Generic Migranal

Generic Migranal is for use only during a genuine attack of classic migraine. Do not attempt to prevent migraines with this drug, and do not use it for tension headaches, cluster headaches, or unusual types of migraine such as hemiplegic or basilar migraine.

Generic Migranal precautions if you are pregnant or breastfeeding

Generic Migranal can harm a developing baby; do not use it during pregnancy. Also avoid while breastfeeding. Generic Migranal appears in breast milk and may cause diarrhea, vomiting, weak pulse, and unstable blood pressure in a nursing infant.

Special warnings about Generic Migranal

• Before you take Generic Migranal, tell your doctor what prescription and non-prescription drugs you are taking, especially erythromycin, nifedipine, prazosin, and propranolol.
• Before you take Generic Migranal, tell your doctor if you have liver, kidney, or blood vessel disease; severe high blood pressure; Raynauds disease; poor circulation; coronary artery disease or a severe infection. Contact your doctor if you develop any kind of infection while taking Generic Migranal.
• If you take large doses of Generic Migranal for a long time, you may have a severe headache for a few days after stopping the drug. If the headache lasts for more than a few days, contact your doctor.
• Do not allow anyone else to take Generic Migranal .

Why Generic Migranal should not be prescribed ?

Do not take Generic Migranal if you have ever had an allergic reaction to ergotamine tartarate, caffeine, belladonna or paracetamol.

You should avoid Generic Migranal if you have certain types of heart or blood vessel disease, including angina (crushing chest pain) or a history of heart attack, or if you suffer from uncontrolled high blood pressure, severe kidney or liver disease, or a severe blood infection. Avoid Generic Migranal, too, if you have recently had blood vessel surgery.

Do not use Generic Migranal within 24 hours of taking another ergotamine-based drug, or another migraine remedy such as Amerge, Imitrex, Maxalt, or Zomig, or the migraine-preventing drug Sansert. Also avoid combining Generic Migranal with other drugs that constrict the blood vessels, such as the decongestants pseudoephedrine and phenylpropanolamine found in many OTC over-the-counter cold products.

More common side effects of Generic Migranal may include:

• Rhinitis
• Altered sense of taste
• Dizziness
• Nausea
• Vomitting
• Application site reaction

• Leg weakness
• Muscle pain or stiffness in the legs, arms, neck or shoulders
• Coldness, numbness and tingling of the fingers and toes
• Abdominal pain

Rare side effects of Generic Migranal may include:

• Chest pain