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	What is Wellbutrin SR and why is it prescribed?

Wellbutrin SR, a relatively new antidepressant medication (related to smoking), is given to help relieve certain kinds of major depression. Major depression involves a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and perhaps thoughts of suicide. Unlike the more familiar tricyclic antidepressants, such as Elavil, Tofranil, and others, Wellbutrin SR tends to have a somewhat stimulating effect. Wellbutrin is available in regular and sustained-release formulations (Wellbutrin SR). Top

	Drug Mechanism: How does Wellbutrin SR work?

Bupropion regulates certain brain chemicals – dopamine and norepinephrine to elevate mood. It is believed that depression is caused by chemical imbalances in the brain. Controlling these chemical imbalances will help improve depressive symptoms using drugs like Wellbutrin SR. Top

	Dosage: How should you take Wellbutrin SR?

Take Wellbutrin SR dose exactly as prescribed by your doctor. The usual Wellbutrin SR dosing regimen is 3 equal doses spaced evenly throughout the day. Allow at least 6 hours between Wellbutrin SR doses. Your doctor will probably start you at a low dosage and gradually increase it; this helps minimize Wellbutrin SR side effects. You should take Wellbutrin SR, the sustained-release form, in 2 doses, at least 8 hours apart. Swallow Wellbutrin SR tablets whole; do not chew, divide, or crush them. If Wellbutrin works for you, your doctor will probably have you continue taking it for at least several months. No single dose of Wellbutrin should exceed 150 milligrams. Wellbutrin SR dose for adults: Wellbutrin: At the beginning, your Wellbutrin dose will probably be 200 milligrams per day, taken as 100 milligrams 2 times a day. After at least 3 days at this dose, your doctor may increase the Wellbutrin dosage to 300 milligrams per day, taken as 100 milligrams 3 times a day, with at least 6 hours between doses. This is the usual adult Wellbutrin dose. The maximum recommended Wellbutrin dosage is 450 milligrams per day taken in doses of no more than 150 milligrams each. Wellbutrin SR dosage: The usual starting dose of Wellbutrin is 150 milligrams in the morning. After 3 days, if you do well, your doctor will have you take another 150 milligrams at least 8 hours after the first dose of Wellbutrin. It may be 4 weeks before you feel the benefit and you will take Wellbutrin SR for several months. The maximum recommended Wellbutrin SR dose is 400 milligrams a day, taken in doses of 200 milligrams each. If you have severe cirrhosis of the liver, your Wellbutrin dosage should be no more than 75 milligrams once a day. With less serious liver and kidney problems, the Wellbutrin dosage will be somewhat reduced. Wellbutrin SR dose for children: The safety and effectiveness of Wellbutrin SR dose in children under 18 years old have not been established. Wellbutrin SR dose for older adults: Although they are more sensitive to antidepressant drugs, older people have responded no differently to Wellbutrin than younger people. Overdose of Wellbutrin SR: Any medication taken in excess can have serious consequences. If you suspect an overdose of Wellbutrin, seek medical attention immediately. Symptoms of Wellbutrin overdose may include: Hallucinations, heart failure, loss of consciousness, rapid heartbeat, seizures Symptoms of Wellbutrin SR overdose may include: Blurred vision, confusion, jitteriness, lethargy, light-headedness, nausea, seizures, vomiting An overdose that involves other drugs in combination with Wellbutrin may also cause these symptoms: Breathing difficulties, coma, fever, rigid muscles, stupor If you miss a dose of Wellbutrin SR: Take it as soon as you remember. If it is within 4 hours of your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses of Wellbutrin SR at the same time. Storage instructions for Wellbutrin SR: Store Wellbutrin SR at room temperature. Protect from light and moisture. Preparations of Wellbutrin Tablets: Wellbutrin 75 mg, Wellbutrin 100 mg Wellbutrin SR 100 mg, Wellbutrin SR 150mg Top

	Possible food and drug interactions when taking Wellbutrin SR

Do not drink alcohol while you are taking Wellbutrin SR; an interaction between alcohol and Wellbutrin SR could increase the possibility of a seizure. If Wellbutrin SR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Wellbutrin SR with the following: Beta-blockers (used for high blood pressure and heart conditions), such as Inderal, Lopressor, and Tenormin, Carbamazepine (Tegretol), Cimetidine (Tagamet), Cyclophosphamide (Cytoxan), Heart-stabilizing drugs such as Rythmol and Tambocor, Levodopa (Larodopa), Major tranquilizers such as Haldol, Risperdal, Thorazine, and Mellaril, MAO inhibitors (such as the antidepressants Parnate and Nardil), Nicotine patches such as Habitrol, NicoDerm CQ, and Nicotrol patch, Orphenadrine (Norgesic), Other antidepressants such as Elavil, Norpramin, Pamelor, Paxil, Prozac, Tofranil, and Zoloft, Phenobarbital, Phenytoin (Dilantin), Steroid medications such as Prednisone, Theophylline (Theo-Dur). Top

	Special information on Wellbutrin SR

Special information if you are pregnant or breastfeeding: If you are pregnant or plan to become pregnant, notify your doctor immediately. Wellbutrin SR should be taken during pregnancy only if clearly needed. Wellbutrin SR does pass into breast milk and may cause serious reactions in a nursing baby; therefore, if you are a new mother, you may need to discontinue breastfeeding while you are taking Wellbutrin SR. Top

	Wellbutrin side effects

Wellbutrin SR Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Wellbutrin SR. Seizures are perhaps the most worrisome side effect of Wellbutrin SR. More common side effects of Wellbutrin: May include, adominal pain (Wellbutrin SR), agitation, anxiety (Wellbutrin SR), constipation, dizziness, dry mouth, excessive sweating, headache, loss of appetite (Wellbutrin SR), nausea, palpitations (Wellbutrin SR), vomiting, skin rash, sleep disturbances, sore throat (Wellbutrin SR), tremor. Other side effects of Wellbutrin SR: May include, acne, allergic reactions (severe), bed-wetting, blisters in the mouth and eyes (Stevens-Johnson syndrome) blurred vision, breathing difficulty, chest pain, chills, complete or almost complete loss of movement, confusion, dry skin, episodes of over-activity, elation, or irritability, extreme calmness, fatigue, fever, fluid retention, flu-like symptoms, gum irritation and inflammation, hair color changes, hair loss, hives, impotence, incoordination and clumsiness, indigestion, itching, increased libido, menstrual complaints, mood instability, muscle rigidity, painful ejaculation, painful erection, retarded ejaculation, ringing in the ears, sexual dysfunction, suicidal ideation, thirst disturbances, toothache, urinary disturbances, weight gain or loss. Top

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