Surmontil (Trimipramine maleate) is an antidepressant.

Surmontil can treat your depression by lifting your mood, especially if it is associated with sleep disturbances. Improvement of sleep patterns and anxiety can be the first benefits of treatment.

Surmontil may be prescribed for other conditions, such as relief from nerve pain.

Surmontil belongs to a group of medicines known as tricyclic antidepressants (TCA).

When depression occurs, there may be a decreased amount of the chemicals noradrenaline and serotonin released from nerve cells in the brain. When these chemicals are released from nerve cells they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood.

Surmontil works by preventing this re-absorption of noradrenaline and serotonin back into the nerve cells. Therefore, it helps prolong the mood-lightening

Take Surmontil by mouth.

Swallow the capsules with a drink of water. You can take the capsules with or without food.

Elderly patients over 65 years old and adolescents may have a stronger reaction to Surmontil and need smaller doses.

Adults
The usual starting dose is 75 milligrams per day, divided into equal smaller doses. Your doctor may gradually increase your dose to 150 milligrams per day, divided into smaller doses. Doses over 200 milligrams a day are not recommended.

If Surmontil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Surmontil with the following:

• Antidepressants such as Desyrel and Wellbutrin
• Antidepressants that act on serotonin, such as Prozac, Paxil, and Zoloft
• Antispasmodic drugs such as Donnatal and Cogentin
• Cimetidine (Tagamet)
• Drugs for heart irregularities, such as Rythmol and Tambocor
• Guanethidine (Ismelin)
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Most Important Fact about Surmontil
People who are taking antidepressants known as MAO inhibitors (Parnate and Nardil) should not take Surmontil . Wait 2 weeks after stopping an MAO inhibitor before you begin taking Surmontil.

Surmontil precautions if you are pregnant or breastfeeding
The safety of Surmontil during pregnancy has not been established. The manufacturer therefore advises that it should be avoided during pregnancy. Seek medical advice from your doctor.

Significant amounts

More common side effects of Surmontil may include:

• dizziness,
• drowsiness,
• dryness of mouth,
• headache,
• increased appetite,
• nausea,
• tiredness or weakness (mild),
• unpleasant taste,
• weight gain

Less common side effects of Surmontil may include:

• blurred vision,
• confusion or delirium,
• constipation, decreased sexual ability,
• difficulty in speaking or swallowing,
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