Sinemet CR (Carbidopa+Levodopa) is used to treat Parkinson s disease. Parkinson s disease is believed to be related to low levels of a chemical called dopamine in the brain.

Levodopa can help correct an imbalance of chemicals in the brain caused by Parkinson s disease. Levodopa will not cure Parkinson s disease, but will help to control the symptoms.

Carbidopa helps Levodopa work better, and this can decrease some side

Sinemet CR contains the active ingredients Levodopa and Carbidopa , sometimes known in combination as co-careldopa. Sinemet CR is used in Parkinson s disease to increase the levels of dopamine in the brain.

Dopamine is a substance known as a neurotransmitter. Neurotransmitters are present in the brain and nervous system and are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in

Take Sinemet CR tablets by mouth. Swallow the tablets with a glass of water.

It is best to take Sinemet CR on an empty stomach, either 30 minutes before you eat or 1 hour after you eat. If Sinemet CR upsets your stomach, you can take Sinemet CR with a fruit.

Adults
For patients with mild to moderate symptoms, the initial recommended dose is 1 tablet of Sinemet CR taken 2 times a day.

Starting doses should be spaced out every 4 to 8 hours and

Tell you doctor what medicines you are taking, including those bought without a prescription and herbal medicines, before you start treatment with Sinemet CR . Similarly, check with your doctor or pharmacist before taking any new medicines while you are taking this one.

Sinemet CR should not be taken at the same time as, or within two weeks of stopping a non-selective monoamine oxidase inhibitor (MAOI), eg the antidepressants phenelzine, tranylcypromine and isocarboxazid, and the antibiotic linezolid. Sinemet CR may be taken with the

Most Important Fact about Sinemet CR
There is also a regular, non-controlled-release form of Sinemet CR ; called Sinemet Over a period of hours, Sinemet CR , the controlled-release form, gives a smoother release of the drug than regular Sinemet . If you have been taking regular Sinemet , be aware that you may need a somewhat higher dosage of Sinemet CR to get the same degree of relief. Your first morning dose of Sinemet CR may take as much as an hour

More common side effects of Sinemet CR may include:

• confusion,
• hallucinations,
• nausea,
• uncontrollable twitching or
• jerking

Less common or rare side effects of Sinemet CR may include:

• abdominal or stomach pain,
• abnormal dreams,
• agitation,
• anemia,
• anxiety,
• back pain,
• bizarre breathing patterns,
• bleeding from stomach,
• blisters,
• blurred
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