What other drugs will affect digoxin?
Before taking digoxin, tell your doctor if you are taking any of the following medicines:
- another medication for irregular heartbeats, such as quinidine (Quinidex, Quinora, Cardioquin, others), amiodarone (Cordarone), or propafenone (Rythmol),
- an antacid or laxative that contains aluminum, magnesium, or kaolin-pectin such as Maalox, Rolaids, Mylanta, Milk of Magnesia, and others,
- a beta-blocker such as atenolol (Tenormin), propranolol (Inderal), acebutolol (Sectral), metoprolol (Lopressor), carteolol (Cartrol), labetalol (Normodyne, Trandate), or nadolol (Corgard),
- a calcium channel blocker such as diltiazem (Cardizem, Dilacor XR, Tiazac), amlodipine (Norvasc), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Verelan, Calan, Isoptin, Covera-HS), and others,
- a cancer chemotherapy drug,
- a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril, others), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), furosemide (Lasix), torsemide (Demadex), bumetanide (Bumex), ethacrynic acid (Edecrin), triamterene (Dyrenium, Maxzide, Dyazide), amiloride (Midamor), spironolactone (Aldactone), eplerenone (Inspra), and others,
- a steroid medicine such as prednisone (Deltasone), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others), dexamethasone (Decadron), and others,
- a thyroid medication,
- alprazolam (Xanax),
- amphotericin B (Fungizone),
- cholestyramine (Questran, Prevalite) or colestipol (Colestid),
- erythromycin (E.E.S., E-Mycin, Eryc, Ery-Tab, PCE, others) or clarithromycin (Biaxin),
- indomethacin (Indocin),
- itraconazole (Sporanox),
- metoclopramide (Reglan),
- rifampin (Rifadin, Rimactane),
- sulfasalazine (Azulfidine)
- tetracycline (Broadspec, Emtet, Panmycin, Sumycin, Tetracap, others).
You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with
digoxin or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
