Drug Mechanism: How does Celecoxib work?

Like older NSAIDs such as Motrin and Naprosyn, Generic Celecoxib 400 mg is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Generic Celecoxib is therefore less likely to cause the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.

Generic Celecoxib 400 mg has also been found to reduce the number of colorectal polyps (growths in the wall of the lower intestine and rectum) in people who suffer from the condition called familial adenomatous polyposis (FAP), an inherited tendency to develop large numbers of colorectal polyps that eventually become cancerous.

Generic Celecoxib 400 mg works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.