Drug Class: What is Vitamin E and why is it prescribed?
Drug Mechanism: How does Vitamin E work?
Dosage: How should you take Vitamin E?
Possible food and drug interactions when taking Vitamin E
Special information on Vitamin E
Vitamin E side effects
|Drug Class: What is Vitamin E and why is it prescribed?|
| Vitamin E is the collective term for a family of chemical substances that are structurally and, in some cases, biologically related to the best known member of this family, alpha-tocopherol. Vitamin E is a fat-soluble vitamin and an essential nutrient for humans. However, in contrast with the other vitamins present in human nutrition, its exact biochemical role remains unknown.
|Drug Mechanism: How does Vitamin E work?|
| Vitamin E has antioxidant activity. It may also have anti-atherogenic, antithrombotic, anticoagulant, neuroprotective, antiproliferative, immunomodulatory, cell membrane-stabilizing and antiviral actions.
Vitamin E is the principal antioxidant of the lipid domains of the body, such as cellular membranes. It is a chain-breaking antioxidant that prevents the propagation of free radical activities. It is a peroxyl radical scavenger and especially protects the polyunsaturated fatty acids (PUFAs) within membrane phospholipids and in plasma lipoproteins (LDL) against
|Dosage: How should you take Vitamin E?|
| Recommended doses for supplementation range from 100 to 400 milligrams daily with a capsule of 1000 milligrams/day for d-alpha-tocopherol in the form of d-alpha-tocopheryl acetate or succinate or 200 to 800 milligrams/day with a capsule of 1000 milligrams/day for d1-alpha-tocopherol in the form of dl-alpha-tocopheryl acetate or succinate.
|Possible food and drug interactions when taking Vitamin E|
The following drugs may react with Vitamin E:
|Special information on Vitamin E|
| Vitamin E is contraindicated in those with known hypersensitivity to any component of a vitamin E-containing product.
Those on warfarin should be cautious in using high doses of vitamin E (i.e., doses greater than 100 milligrams daily of d-alpha-tocopherol or 200 milligrams daily of d1-alpha-tocopherol), and if they do use such doses, they should have their INRs monitored and their warfarin dose appropriately adjusted if indicated. Likewise, those with vitamin K deficiencies, such as those with liver failure, should be cautious in using high
|Vitamin E side effects|
| The risk of adverse reactions to vitamin E supplementation (in doses up to one gram daily of alpha-tocopherol) generally appears to be very low.
Adverse reactions reported for vitamin E supplementation include fatigue, breast soreness, emotional disturbances, thrombophlebitis, retinuria, gastrointestinal disturbances, altered serum lipid levels and thyroid problems. These adverse reactions may be rare and none of these has been reported in controlled studies. An increased incidence of necrotizing enterocolitis has been reported in premature, very-low birth
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