The delayed-release tablets are also used to control the manic episodes--periods of abnormally high spirits and energy--that occur in bipolar disorder (manic depression).

An extended-release form of this drug, Depakote ER, is prescribed to prevent migraine headaches. The delayed-release tablets are also used for this purpose.

If you are taking the sprinkle capsule, you can swallow it whole or open it and sprinkle the contents on a teaspoon of soft food such as applesauce or pudding. Swallow it immediately, without chewing. The sprinkle capsules are large enough to be opened easily.

Depakote can be taken with meals or snacks to avoid stomach upset. Take it exactly as prescribed.

If you miss a Depakote dose:

If Depakote is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Depakote with the following:

• Amitriptyline (Elavil),
• Aspirin,
• Barbiturates such as phenobarbital and Seconal,
• Blood thinners such as Coumadin,
Top | Read More on Possible food and drug interactions when taking this medication

Depakote can severely damage the liver (see \\\"Most important fact about this drug\\\"). Your doctor will test your liver function before you begin taking

More common Side effects of Depakote may include:
Abdominal pain, abnormal thinking, breathing difficulty, bronchitis, bruising, constipation, depression,