Kytril (Granisetron) is used to prevent and treat nausea and vomiting associated with cancer chemotherapy, radiation therapy, and anesthesia used during surgery.

Kytril blocks the actions of chemicals in the body that may cause nausea and vomiting.

Kytril may also be used for purposes other than those listed above.

Kytril is a serotonin receptor blocker that acts in the brain and gut, although the exact way it works is unknown. It is thought that serotonin receptor blockade prevents signals from reaching the vomiting centre in the brain and thereby prevents vomiting.

Anti-cancer medicines and radiotherapy may cause the release of serotonin in the small intestine, setting off the vomiting reflex. Kytril blocks this process

For prevention of nausea and vomiting caused by anticancer medicine:

Adults and teenagers
Dose of Kytril is usually 1 milligram (mg) taken up to one hour before the anticancer medicine. The 1-mg dose is taken again twelve hours after the first dose of Kytril. Alternatively, 2 mg may be taken as one dose, up to one hour before the anticancer medicine.

Children
Your doctor must determine dose of Kytril.

For prevention of nausea and vomiting caused by radiation therapy:
Adults and teenagers
Dose

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Kytril works. Check with your health care professional before stopping or starting any of your medicines.

Why Kytril should not be prescribed ?
Kytril should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you

More common side effects of Kytril may include:

• abdominal pain,
• constipation,
• diarrhea,
• headache,
• unusual tiredness or
• weakness

Less common side effects of Kytril may include:

• agitation,
• dizziness,
• drowsiness,
• heartburn,
• indigestion,
• sour stomach,
• trouble in sleeping,
• unusual taste in mouth,
• fever

Rare side