Drug Class: What is Methotrexate and why is Methotrexate prescribed?
Drug Mechanism: How does Methotrexate work?
Dosage: How should you take Methotrexate?
Possible food and drug interactions with Methotrexate
Special information on Methotrexate
Possible Methotrexate side effects
|Drug Class: What is Methotrexate and why is Methotrexate prescribed?|
Methotrexate is an anticancer drug used in the treatment of lymphoma (cancer of the lymph nodes) and certain forms of leukemia. Methotrexate is also given to treat some forms of cancers of the uterus, breast, lung, head, neck, and ovary. Methotrexate interferes with the production and maintenance of DNA, which is the genetic material in the cells of the body. Methotrexate has a greater effect on cells that reproduce often such as cancer cells, bone marrow cells, skin cells, and others.
|Drug Mechanism: How does Methotrexate work?|
Methotrexate is a type of medicine called a cytotoxic antimetabolite. It is used to treat three different conditions: rheumatoid arthritis, psoriasis and cancer of various types.
Cancers form when cells within the body multiply uncontrollably and abnormally. These cells then spread and destroy nearby tissues. Methotrexate works by preventing the cancer cells from dividing and multiplying. Methotrexate does this by inhibiting the action of an enzyme called dihydrofolate reductase. This enzyme normally converts folic acid into a substance
|Dosage: How should you take Methotrexate?|
Take Methotrexate exactly as prescribed, and promptly report to your doctor any new symptoms that may develop.
Take each oral dose of Methotrexate with a full glass of water.
Methotrexate is given at a higher dosage for cancer than for psoriasis or rheumatoid arthritis. After high-dose Methotrexate treatment, a drug called leucovorin may be given to limit the toxic effects.
Do not take more of Methotrexate than is prescribed. Too much Methotrexate can be dangerous,
|Possible food and drug interactions with Methotrexate|
If you are being given Methotrexate for the treatment of cancer or psoriasis, you should not take aspirin or other non-steroidal painkillers such as Advil or Naprosyn; this combination could increase the toxic effects of Methotrexate If you are taking Methotrexate for rheumatoid arthritis, you may be able to continue taking aspirin or a non-steroidal painkiller, but your doctor should monitor you carefully.
Other drugs that may increase the toxic effects of methotrexate include:
|Special information on Methotrexate|
Most important fact about Methotrexate
|Possible Methotrexate side effects|
Side effects of Methotrexate cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine whether it is safe for you to continue taking Methotrexate.
More common side effects of Methotrexate may include:
Less common side effects of Methotrexate may include:
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