Pletal (Cilostazol) is a medication that reduces the symptoms of intermittent claudication. This condition causes pain in the legs during walking, and goes away with rest.

Pletal helps blood flow more smoothly through the blood vessels; this action improves oxygen flow to the tissues of the body. By improving blood flow, Pletal helps people with claudication walk longer distances without pain. In some cases Pletal may be prescribed for other health conditions where improved blood flow

Intermittent claudication results from impaired blood supply to the legs. Although its precise mechanism of action is not clear, Ponstel appears to improve circulation by dilating blood vessels, especially those supplying the legs. Ponstel also appears to inhibit the aggregation (clumping) of platelets and this reduces the formation of blood clots, which can block arterial blood flow.

Take Pletal by mouth. Swallow the Pletal capsules with plenty of water (at least a full glass) to avoid stomach upset. Take on an empty stomach, at least ½ hour before or 2 hours after a meal.

For treatment of peripheral vascular disease (circulation problems):

Adults
100 milligrams of Pletal two times a day, taken an hour before or two hours after breakfast and dinner.

Children
Your doctor must determine use and dose of Pletal .

If you miss a Pletal dose
Take Ponstel

• agents that prevent or treat blood clots (such as enoxaparin or warfarin)
• antiinflammatory drugs (NSAIDs, such as ibuprofen, naproxen, or ketoprofen)
• aspirin
• cimetidine
• clopidogrel
• diltiazem
• erythromycin or clarithromycin
• fish oil (omega-3 fatty acids) supplements
• herbal medicines or dietary supplements like feverfew, garlic pills, ginger, gingko biloba, or horse chestnut
• grapefruit juice
• omeprazole
• pentoxifylline
• some
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Most Important Fact about Pletal

Patients with congestive heart failure should not use Pletal. If you have a history of heart disease, talk to your doctor about the potential risks associated with Pletal before taking it.

Pletal precautions if you are pregnant or breastfeeding
Tell your doctor if you are pregnant or if you intend to become pregnant. Studies in rats and rabbits have shown that Pletal may cause some birth defects. Be sure that you have discussed this with your doctor before

More common side effects of Pletal may include:

• headache,
• heart palpitations,
• diarrhea,
• increased risk of infection.

Less common side effects of Pletal may include:

• rapid heartbeat,
• abdominal pain,
• indigestion,
• flatulence,
• nausea,
• swelling of the extremities,
• dizziness,
• sore throat,
• runny nose.