Pyrazinamide is an antibiotic that is used to treat or prevent tuberculosis infections. Other medicines for tuberculosis are used in combination with Pyrazinamide; it should never be used alone.

Pyrazinamide is an antibiotic that is used to kill the bacteria that cause tuberculosis (TB). When Pyrazinamide enters a tuberculosis-infected cell, it sets off a chain of chemical reactions that kills the bacteria.

There are two stages in the treatment of tuberculosis. In the first two months after infection (the initial phase), treatment is aimed at killing as many bacteria as possible. Therefore several anti-TB drugs with different mechanisms of action are used in

Take Pyrazinamide tablets by mouth. Pyrazinamide can be taken with or without food.

Adults
1.5 to 2.5 gm of Pyrazinamide per day.

Children
6.8 to 13.6 mg per lb once a day; not more than 2,000 mg daily. Pyrazinamide may also be given to adults or children 2 to 3 times a week in a dose of 22.7 to 31.8 mg per lb. If the schedule is twice a week, adults should take no more than 4,000 mg per dose; if the schedule is 3 times a week, no more than 2,500 mg per dose. Children should receive not more than

The following drugs may interact with Pyrazinamide

• alcohol
• allopurinol
• colchicine
• probenecid
• sulfinpyrazone

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Pyrazinamide

Most Important Fact about Pyrazinamide
Take Pyrazinamide as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy. Treatment may continue for months or years. The decision to stop taking Pyrazinamide should be made by your doctor

Pyrazinamide precautions if you are pregnant or breastfeeding

The safety of Pyrazinamide during pregnancy has not been established. Seek medical advice from your doctor.

Pyrazinamide passes into

More common side effects of Pyrazinamide may include:

• pain in large and small joints

Less common side effects of Pyrazinamide may include:

• loss of appetite,
• pain and swelling of joints, especially big toe, ankle, and knee,
• tense, hot skin over affected joints,
• unusual tiredness or weakness,
• yellow eyes or skin,
• itching,
• skin rash