Drug class: what is tadalafil and why is it prescribed?
Drug mechanism: how does tadalafil work?
Dosage: how should you take tadalafil?
Possible food and drug interactions when taking tadalafil
Special information on tadalafil
Tadalafil side effects
|Drug class: what is tadalafil and why is it prescribed?|
Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).
Tadalafil is an oral drug that is used to treat impotence (the inability to attain or maintain a penile erection). it is a phosphodiesterase inhibitor that is similar to sildenafil citrate and vardenafil.
|Drug mechanism: how does tadalafil work?|
Erections are caused by increased blood flow from the relaxation of penile arteries and corpus cavernosal smooth muscle. Cyclic GMP (cGMP) causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. During sexual stimulation, tadalafil will inhibit phosphodiesterase type 5 PDE5, which increases the amount of cGMP in smooth muscles cells thus enhancing erectile function.
Penile erection is caused by the engorgement of the penis with blood. this engorgement occurs when the blood vessels delivering blood to the penis increase in size and
|Dosage: how should you take tadalafil?|
Usual Adult Dose for Erectile Dysfunction
Use as needed for ED:
Comment: Consider that this drug has shown to improve erectile dysfunction up to 36 hours following dosing, when used as needed.
Once a day use for ED:
|Possible food and drug interactions when taking tadalafil|
The breakdown and elimination of tadalafil from the body may be decreased by erythromycin, ketoconazole (nizoral), itraconazole (sporanox), indinavir (crixivan) and ritonavir (norvir).
therefore, these drugs may increase the concentration of tadalafil in the blood. if these drugs are being used at the same time as tadalafil, the dose of tadalafil should be reduced in order to avoid side effects from high levels of tadalafil.
tadalafil increases the heart rate and also exaggerates the blood pressure
|Special information on tadalafil|
Tadalafil is not approved for use in pregnant women. tadalafil has not been evaluated in women who are breastfeeding.
|Tadalafil side effects|
The most common tadalafil side effects are facial flushing (reddening), headaches, stomach upset, diarrhea, flu-like symptoms and nausea.
tadalafil also may cause chest pain, low blood pressure, blurred vision and changes in color vision, abnormal ejaculation and priapism (prolonged and painful erection).
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