Drug Class: What is Prasugrel and why is it prescribed?
Drug Mechanism: How does Prasugrel work?
Dosage: How should you take Prasugrel?
Possible food and drug interactions when taking Prasugrel
Special information on Prasugrel
Prasugrel side effects
|Drug Class: What is Prasugrel and why is it prescribed?|
|Prasugrel is an oral anti-platelet medicine specifically for patients who have undergone an angioplasty procedure to open up a blocked heart artery after experiencing a heart attack or heart-related chest pain at rest (unstable angina) – both these medical conditions are known as acute coronary syndrome. Prasugrel was approved by the US Food and Drug Administration for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI in 2009.|
|Drug Mechanism: How does Prasugrel work?|
|Prasugrel is a prodrug, oxidation by intestinal and hepatic cytochrome P-450 enzymes convert prasugrel into its active metabolite. Prasugrel has a rapid and almost complete absorption after oral ingestion of a loading dose. Its active form binds irreversibly to the adenosine diphosphate (ADP) P2Y12 receptor on platelets for their lifespan, thereby inhibiting their activation and decreasing subsequent platelet aggregation.|
|Dosage: How should you take Prasugrel?|
|Take this medicine by mouth with a drink of water. Follow the directions on the prescription label. You may take this medicine with or without food. Do not cut, crush or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor s advice. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.|
|Possible food and drug interactions when taking Prasugrel|
|Taking certain medications with prasugrel can lead to drug interactions. Some of the medicines that can interfere with the antiplatelet drug include NSAIDs (such as diclofenac and ibuprofen) and warfarin. Taking these products together increases your risk for bleeding problems. Therefore, make sure your healthcare provider has a complete list of all your current medications.|
|Special information on Prasugrel|
|If you have any active bleeding, such as a bleeding stomach, you should not take prasugrel. Precautions and warnings for the antiplatelet drug also apply to people with liver disease, people who have had a stroke, and women who are pregnant or breastfeeding. This drug should be avoided by anyone who is allergic to prasugrel or any of its active ingredients.|
|Prasugrel side effects|
Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health
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