Drug Mechanism: How does Clomid work?

Generic Clomid 50 mg (Clomiphene) is the most commonly used drug in cases where lack of ovulation in the female body is preventing pregnancy. Ovulation, which is essential for the regular menstrual cycle and for pregnancy, is preceded by a chain of events involving several hormones and beginning during the prior menstrual cycle.

Generic Clomid 50 mg works by influencing the interaction of these four hormones: GnRH (gonotropin releasing hormone), FSH (follicle stimulating hormone), LH (luteinizing hormone), Estradiol. Toward the end of a normal cycle, the body s levels of estrogen and progesterone slowly decrease. During the first days of the next menstrual cycle, the lower levels of those two hormones eventually trigger production of GnRH in the hypothalamus. GnRH then stimulates the pituitary gland to produce FSH and LH, also called gonatropins, which directly affect ovulation: FSH is responsible for the growth of both follicles and eggs and for increasing the size and number of the follicles.

The level of LH suddenly increases one to two days before ovulation, which causes the eggs to be released. Estradiol is a hormone produced by the ovaries and the corpus luteum, or tissue left behind in the ovary after ovulation. Among other things, estradiol aids in the development of the uterine lining and the eggs. If GnRH, LH, or FSH are not produced in the right amount and at the right time, the ovaries won t release eggs.

In some medical conditions such as polycystic ovary syndrome, the body produces too much estrogen, which may interfere with the production of GnRH, LH, and FSH and cause an ovulation. Although a lot about how Generic Clomid 50 mg works is still not known, we do know that it tricks the body into believing that the body s estrogen level is low. The body then produces more GnRH, causing the pituitary to pump out more of FSH and LH eventually triggering the release of an egg from the ovary.

Generic Clomid 50 mg a very powerful drug and induces ovulation in more than 50% of women who take it. Generic Clomid 50 mg is usually taken in pill form once a day for five days. Generic Clomid 50 mg (Clomiphene citrate) was approved by the FDA in the U.S. in 1967.