Possible food and drug interactions when taking Sulphamethoxazole - TMP

If Sulphamethoxazole - TMP 400/800 mg is taken with certain other drugs, the effects of Sulphamethoxazole - TMP 400/800 mg, either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sulphamethoxazole - TMP 400/800 mg with the following: Amantadine (Symmetrel), Blood thinners such as Coumadin, Cyclosporine (Neoral, Sandimmune), Digoxin (Lanoxin), Indomethacin (Indocin), Methotrexate (Rheumatrex), Oral diabetes medications such as Micronase and Glucotrol, Pyrimethamine (Daraprim), Seizure medications such as Dilantin, Tricyclic antidepressants such as Elavil, Norpramin, Sinequan, and Tofranil, Water pills (diuretics) such as HydroDIURIL.