Vioxx

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	Drug Class: What is Vioxx and why is it prescribed?

Vioxx, Rofecoxib is a new kind of painkiller used in the treatment of osteoarthritis, rheumatoid arthritis, painful menstruation (dysmenorrhea), and other types of acute pain. It is a member of the family of nonsteroidal anti-inflammatory drugs (NSAIDs) called "COX-2 inhibitors." Other drugs in this family include Celebrex and Bextra. Like older NSAIDs such as aspirin, Motrin, and Naprosyn, these newer drugs are believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however, the newer drugs do not interfere with a similar Top \| Read More on Drug Class: What is Vioxx and why is it prescribed?

	Drug Mechanism: How does Vioxx work?

Prostaglandins are chemicals that are important in promoting inflammation and its signs--pain, fever, swelling and tenderness. Vioxx, Rofecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase- 2) and thereby reduces the amounts of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness also are reduced. Rofecoxib is similar to celecoxib (Celebrex). Both drugs differ from other NSAIDs in that they cause less irritation and ulceration of the stomach and intestine (at least during short-term treatment), and they do not interfere with Top \| Read More on Drug Mechanism: How does Vioxx work?

	Dosage: How should you take Vioxx?

Vioxx may be taken with or without food. If it has been prescribed for arthritis, be sure to take it faithfully once every day. Vioxx suspension should be thoroughly shaken before each use. ADULTS Osteoarthritis: The usual starting dose is 12.5 milligrams once daily. The doctor may increase your dose to a maximum of 25 milligrams once daily if needed. Rheumatoid Arthritis: The recommended dose is 25 milligrams once daily. Taking any more than this on a regular basis is not recommended. Acute Pain and Dysmenorrhea: The recommended dose is 50 milligrams once daily as needed, for Top \| Read More on Dosage: How should you take Vioxx?

	Possible food and drug interactions when taking Vioxx

If Vioxx is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Vioxx with the following: Aluminum and magnesium antacids such as Maalox and Mylanta, Amitriptyline (Elavil), Aspirin, Blood pressure medications known as ACE-inhibitors, including Capoten, Lotensin, and Vasotec, Calcium carbonate antacids such as Alka-Mints and Tums, Lithium (Eskalith, Lithobid), Methotrexate (Rheumatrex), Rifampin (Rifadin, Rimactane), Tacrine (Cognex), Theophylline (Theo-Dur), Warfarin Top \| Read More on Possible food and drug interactions when taking Vioxx

	Vioxx side effect

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Vioxx. More common side effects may include: Abdominal pain, diarrhea, dizziness, headache, heartburn, high blood pressure, indigestion, nausea, respiratory tract infections, stomach discomfort, swelling of the legs and ankles. Less common side effects may include: Back pain, bronchitis, fatigue, flu-like symptoms, sinus inflammation, urinary tract infections, weakness. Rare side effects may include: Top \| Read More on Vioxx side effect

	Why should this drug be not prescribed?

Do not take Vioxx if aspirin and other NSAIDs have ever given you asthma, hives, or other allergic symptoms. SPECIAL WARNINGS ABOUT THIS MEDICATION: If you develop swelling of the face, tongue, and throat, or begin to have difficulty breathing after taking a dose of Vioxx, seek medical help immediately. You may be having a serious allergic reaction to the drug. Vioxx occasionally causes liver problems. Warning signs include nausea, fatigue, rash, itching, right upper stomach pain, flu-like symptoms, and yellowing of the skin and eyes. If you develop these symptoms, stop taking Vioxx and Top \| Read More on Why should this drug be not prescribed?



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