Vioxx, Rofecoxib is a new kind of painkiller used in the treatment of osteoarthritis, rheumatoid arthritis, painful menstruation (dysmenorrhea), and other types of acute pain. It is a member of the family of nonsteroidal anti-inflammatory drugs (NSAIDs) called \"COX-2 inhibitors.\" Other drugs in this family include Celebrex and Bextra.

Like older NSAIDs such as aspirin, Motrin, and Naprosyn, these newer drugs are believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however,

Prostaglandins are chemicals that are important in promoting inflammation and its signs--pain, fever, swelling and tenderness.

Vioxx, Rofecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase- 2) and thereby reduces the amounts of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness also are reduced.

Vioxx, Rofecoxib is similar to celecoxib (Celebrex). Both drugs differ from other NSAIDs in that they cause less irritation and ulceration of the stomach and

Vioxx may be taken with or without food. If it has been prescribed for arthritis, be sure to take it faithfully once every day. Vioxx suspension should be thoroughly shaken before each use.

Vioxx dosage for adults:

• Osteoarthritis: The usual starting dose of Vioxx is 12.5 milligrams once daily. The doctor may increase your dose to a maximum of 25 milligrams once daily if needed.
• Rheumatoid Arthritis: The recommended dose of Vioxx is 25
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If Vioxx is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Vioxx with the following: Aluminum and magnesium antacids such as Maalox and Mylanta, Amitriptyline (Elavil), Aspirin, Blood pressure medications known as ACE-inhibitors, including Capoten, Lotensin, and Vasotec, Calcium carbonate antacids such as Alka-Mints and Tums, Lithium (Eskalith, Lithobid), Methotrexate (Rheumatrex), Rifampin (Rifadin, Rimactane), Tacrine

Side effects of Vioxx cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Vioxx.

More common side effects of Vioxx: May include, abdominal pain, diarrhea, dizziness, headache, heartburn, high blood pressure, indigestion, nausea, respiratory tract infections, stomach discomfort, swelling of the legs and ankles.

Less common side effects of Vioxx: May include, back pain, bronchitis,

Do not take Vioxx if aspirin and other NSAIDs have ever given you asthma, hives, or other allergic symptoms.

Special warnings about Vioxx: If you develop swelling of the face, tongue, and throat, or begin to have difficulty breathing after taking a dose of Vioxx, seek medical help immediately. You may be having a serious allergic reaction to the drug. Vioxx occasionally causes liver problems. Warning signs include nausea, fatigue, rash, itching, right upper stomach pain, flu-like symptoms, and