Drug Mechanism: How does it work?

Leukotrienes are a group of naturally occurring chemicals in the body that promote inflammation in asthma and seasonal allergic rhinitis and in other diseases in which inflammation is important (such as allergy). They are formed by cells, released, and then bound to other cells, and it is the binding to these other cells that stimulates the cells to promote inflammation. Generic Singulair 10 mg (Montelukast) works in a manner similar to zafirlukast (Accolate), blocking the binding of some leukotrienes. Unlike zafirlukast, Generic Singulair 10 mg (montelukast) does not inhibit CYP2C9 or CYP3A4, two enzymes in the liver that are important in breaking down and eliminating many drugs. Therefore, unlike zafirlukast, Generic Singulair 10 mg (montelukast) is not expected to affect the elimination of other drugs. The safety and effectiveness of Generic Singulair 10 mg has been demonstrated in children as young as 6 years of age. It was approved by the FDA in 1998.